Folks, I'm still having trouble with some failures that appear to be specific to Linux on AMD64, if anyone with access to such a platform can help me out I'd be most grateful. You can test whether your machine exhibits the issue by: cd into libs/math/test and bjam gcc test_hypergeometric_dist1 If that fails, then I'm looking for the output from the following program to try and track down the cause of the error (caution this will be quite voluminous!): #define BOOST_MATH_INSTRUMENT #include "boost/math/distributions.hpp" int main() { double x = 30520, r = 130605, n = 130605, N = 523360, p = 1.315394088731268169855067478460234e-53, q = 1; boost::math::hypergeometric_distribution<> hyp(r, n, N); unsigned x_found = quantile(hyp, p); BOOST_MATH_INSTRUMENT_VARIABLE(x_found); return 0; } Perplexed yours, John.