I have successful compiled an application on my Debian-10 platform using boost-1-67. It is an essential part of my computations chemistry pipe line. Now Debian 11 has been released. I have installed it in a VM in order to make sure that the app is compilable in Debian 11 with boost-1-74 (the Debian12 version of boost), before upgrading my Linux platform. I installed boost in /user/ilocal. The makefile is: BASE=/usr/local BOOST_VERSION=1_74_0 BOOST_INCLUDE = $(BASE)/include C_PLATFORM= -pthread GPP=g++ C_OPTIONS= -O3 -DNDEBUG BOOST_LIB_VERSION= include ../../makefile_common The test compile went well until the link stage. The process stopped with: g++ -pthread -ansi -Wno-long-long -O3 -DNDEBUG -I /usr/local/include -L/usr/local/lib -L. -o gwovina main.o cache.o coords.o current_weights.o everything.o grid.o szv_grid.o manifold.o model.o gwo.o gwo_mutate.o my_pid.o naive_non_cache.o non_cache.o parallel_gwo.o parse_pdbqt.o pdb.o quasi_newton.o quaternion.o random.o ssd.o terms.o weighted_terms.o rotamer.o -l boost_system -l boost_thread -l boost_program_options /usr/bin/ld: cannot find -lboost_system /usr/bin/ld: cannot find -lboost_thread /usr/bin/ld: cannot find -lboost_program_options collect2: error: ld returned 1 exit status make: *** [../../makefile_common:34: gwovina] Error 1 Even my limited knowledge (my original programming experience was with FORTRAN II in the early 1960's), I can see the the problem. Unfortunately, I don't know the solution. Assistance will be greatly appreciated. Thanks om advance. -- Stephen P. Molnar, Ph.D. www.molecular-modeling.net 614.312.7528 (c) Skype: smolnar1